Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2864740 | The American Journal of the Medical Sciences | 2009 | 9 Pages |
Abstract
The obese Zucker rat (OZR) spontaneously develops hyperlipidemia, insulin resistance, and microalbuminuria. In this study, the initial metabolic, functional, and glomerular pathology in young OZR fed with an atherogenic diet resembles the characteristics of metabolic syndrome. Hyperlipidemia and other metabolic derangement cause early glomerular damage in OZR by 10Â weeks of age, before overt diabetes is developed. Consequently, the effects of potential interventions should also be evaluated at the young age. In OZR fed with an atherogenic high-fat diet, low (5Â mg/kg) and high (20Â mg/kg) dosages of rosuvastatin started at 5Â weeks and maintained for 10Â weeks induced a significant improvement in metabolic abnormalities, blood pressure, and renal function, including microalbuminuria. The low dose of rosuvastatin significantly decreased mesangial expansion, and the high dose exerted a marked protective effect on the development of both glomerular hypertrophy and mesangial expansion. The statin also attenuated the inflammatory expression in the kidney cortex.
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Authors
Efrain MD, Jie MD, PhD, Benjamin S. MD, Michelle MD, Erwin A. PharmD, MSc, MPH, Stephen A. DO, MPH, Philip J. PhD, Joseph BVSc, MVSc, PhD, Xuejiao MD,