Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2865042 | The American Journal of the Medical Sciences | 2008 | 5 Pages |
Abstract
Squalene is a type of oil obtained from shark liver. We describe a 76-year-old man diagnosed with chronic exogenous lipoid pneumonia due to squalene. A chest CT scan revealed pulmonary consolidation with ground-glass opacities in the right upper lobe. Positron emission tomography (PET) revealed significant uptake of 2-deoxy-2-18F-fluoro-d-glucose (FDG) and 3â²-deoxy-3â²-18F-fluorothymidine (FLT). Bronchoalveolar lavage (BAL) fluid contained many lipid-laden macrophages, and a transbronchial lung biopsy specimen showed clusters of foamy macrophages in alveolar spaces and granulomatous lesions. In addition, the presence of squalene in the BAL fluid was confirmed by gas chromatography-mass spectrometry, leading to a diagnosis of squalene-induced lipoid pneumonia. To the best of our knowledge, this is the first report of squalene-induced lipoid pneumonia in which squalene itself was successfully detected. This case also suggests the possibility that lipoid pneumonia shows significant uptake in FDG-PET and FLT-PET.
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Authors
Nobuhiro MD, Shuji MD, Koshiro MD, Toshihiko MD, Kyuichi MD, Reiji MD, Toru CT, IAC, Kohoji CT, IAC, Yoshio MD, Yuka MD,