Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2867835 | Angiología | 2009 | 10 Pages |
Abstract
Introduction. Current assessment of asymptomatic infrarenal abdominal aortic aneurysms (AAA) is done solely with serial image techniques. We try to find a useful serological biomarker of AAA activity with potential prognostic value. Patients and methods. We obtained peripheral blood samples from 35 AAA patients (13 3-3.9 cm AAA; 11 4-4.9 cm AAA; 11 > = 5 cm AAA) and 35 controls. We quantified the serum concentration of C-reactive protein (CRP), alphα1-antitrypsin and lipoprotein(a). We registered: clinical data, aortic diameter (ultrasound/CT) at the time of blood sample harvest, and AAA growth in the previous 12 months. We analysed the correlation between each protein and the aortic diameter and growth, using Mann-Whitney, Kruskal-Wallis and Spearman's tests and linear regression. Results. The AAA patients were mostly male (n = 33; 94.3%) and aged 71 ± 6.8 (54-83) years. The AAA diameter (n = 35) was 45 ± 12 (30-71) mm, with expansion (n = 25) 3,1 ± 3,1 (0-10) mm/previous year. The levels of the three proteins were significantly higher in the AAA patients compared to the controls: CRP 4.1 (1.9-7.3) v. 1.9 (0.5-5) mg/L (p = 0.026); alphα1-antitrypsin 147 (131-168) v. 125.5 (114-135.5) mg/dL (p < 0.0001); lipoprotein(a) 47 (20-117.5) v. 27 (9-47) mg/dL (p = 0.022). We found positive correlations CRP-AAA diameter (r = 0.46; p = 0.007) and alphα1-antitrypsin-AAA growth (r = 0,55; p = 0,004), but no association between lipoprotein(a) and AAA diameter or expansion (p > 0.52). CRP concentrations were influenced by statin intake (p = 0.036). There were no correlations for any of the proteins in the control group (p > 0.22). Conclusions. Alphα1-antitrypsin seems promising as a biomarker of AAA activity. CRP shows correlation with AAA size, but is influenced by statin intake. Lipoprotein(a) has not proved useful. [ANGIOLOGÍA 2009; 61: 119-31]
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Authors
M. Vega-De Céniga, M. Esteban-Salan, J.M. Quintana-López, A. Barba-Vélez, L. Estallo-Laliena, N. de la Fuente-Sánchez, B. Viviens-Redondo, S. GarcÃa-Gutiérrez, U. Aguirre-Larracoechea,