| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2872069 | The Annals of Thoracic Surgery | 2014 | 8 Pages |
Abstract
Lung CSCs express higher levels of sPLA2 than the non-stem cell population. Our findings that viral knockdown and chemical inhibition of sPLA2 reduce tumorsphere formation in lung cancer cells demonstrate for the first time that sPLA2 plays an important role in CSCs. These findings suggest that sPLA2 may be an important therapeutic target for human lung cancer.
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Authors
Daine T. MD, Xin-Sheng PhD, Jessica A. MD, Marshall T. MD, David C. MD, Xianzhong PhD, T. Brett MD, David A. MD, Michael J. MD,