Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis

Article ID	Journal	Published Year	Pages	File Type
2873323	The Annals of Thoracic Surgery	2014	7 Pages	PDF

Abstract

Acute myocardial IRI, in healthy pigs treated with rapamycin, is associated with decreased cardiac function and higher myocardial necrosis.

Keywords

cTnI ADP TTC AAR LPF ECL FKBP12 mTOR EGTA RIPA PVDF RyR RLV relaxation time constant mechanistic target of rapamycin complex PKC mTORC IRI adenosine diphosphate radio-immunoprecipitation assay Ischemia-reperfusion injury Akt ethylene glycol tetraacetic acid left ventricle analysis of variance ANOVA Enzyme-linked immunosorbent assay ELISA standard error of the mean Risk Tau polyvinylidene difluoride pressure-volume cardiac troponin I LAD SEM area at risk sodium nitroprusside Mechanistic target of rapamycin Ribosomal protein S6 protein kinase B Protein kinase C SNP left anterior descending Ryanodine receptor

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis

Authors

Antonio D. MD, Nassrene Y. MD, Arthus V.D. Zanetti, Jun MD, PhD, Javier BS, Reginald Y. MD, Frank W. MD, Cesario MD, PhD,