Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2875856 | The Annals of Thoracic Surgery | 2012 | 8 Pages |
Abstract
Assessment of subtle neurocognitive decline after surgical procedures has been hampered by heterogeneous testing techniques and a lack of reproducibility. This review summarizes the sensitivity and specificity of biomarkers of neurologic injury to determine whether they can be applied in the postoperative period to accurately predict neurocognitive decline. Creatine kinase-brain type, neuron-specific enolase, and S100B can be released into serum during operations by extracranial sources. Glial fibrillary acidic protein is a sensitive marker, and there are extracranial sources that are antigenically different from the brain-derived form. Serum levels of tau protein after acute neurologic injury do not reliability correlate with incidence.
Keywords
TBIAISMMP-9PDGFVCAM-1GFAPCPBNSEpNfHTGF-βCeANeuron-specific enolaseTraumatic brain injuryCarotid endarterectomyinterleukincardiopulmonary bypasstransforming growth factor-βtumor necrosis factor-αCABGintracerebral hemorrhageCNSBlood–brain barrierBBBacute ischemic strokecentral nervous systemperipheral nervous systemVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorTNF-αMatrix metalloproteinase 9CSFCerebrospinal fluidICHVascular cell adhesion molecule 1neurofilamentGlial fibrillary acidic proteinCoronary artery bypass graftPNS
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Authors
Michael BMedSc, J. James B. MBBS(Hons), Michael K. FRACS, Paul G. PhD, FRACS, Michael P. PhD, FRACS,