Cerebrospinal Fluid Markers of Brain Injury, Inflammation, and Blood-Brain Barrier Dysfunction in Cardiac Surgery

Article ID	Journal	Published Year	Pages	File Type
2876020	The Annals of Thoracic Surgery	2012	7 Pages	PDF

Abstract

Cardiac surgery with cardiopulmonary bypass causes cerebral inflammation, glial cell injury, and BBB dysfunction without biochemical signs of neuronal damage. These changes are not associated with intraoperative microembolization.

Keywords

CPB RMCA t-tau SAVR NF-L NSE GFAP TCD Neuron-specific enolase cardiopulmonary bypass Total tau surgical aortic valve replacement TCD, Transcranial Doppler blood brain barrier BBB microembolic signals mean arterial pressure CSF Cerebrospinal fluid MeS map Glial fibrillary acidic protein

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Cerebrospinal Fluid Markers of Brain Injury, Inflammation, and Blood-Brain Barrier Dysfunction in Cardiac Surgery

Authors

Björn MD, PhD, Sven-Erik MD, PhD, Henrik MD, PhD, Kaj MD, PhD, Johan MD, Anne MD, PhD,