| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2876022 | The Annals of Thoracic Surgery | 2012 | 7 Pages |
Abstract
Transmyocardial revascularization induces transmigration and engraftment of circulating MSCs. Post TMR, the transcription of SCF and c-kit is rapid and corresponds temporally to MSC engraftment, while SDF-1 levels rise slowly. The CXCR4 is also transiently upregulated. The TMR-augmented repair of infarcted hearts by stem cell transplantation may be mediated by a novel mechanism: transmigration and engraftment of circulating progenitor cells.
Keywords
α-SMALVEDAtransmyocardial revascularizationSex-determining Region on the Y ChromosomePI-3ddH2OLVESVLVEDVIscove modified Dulbecco mediumIMDMCXCL12SCFCXCR4MMP-9MSCSDF-1FASGFPFBSTMRCTRLEPCDNAdistilled deionized waterAlpha-smooth muscle actinStromal derived factor-1deoxyribonucleic acidRNAribonucleic acidleft ventricleLeft ventricular end-diastolic volumeleft ventricular end-systolic volumeIntravenousfetal bovine serumMesenchymal stem cellEndothelial progenitor cellSryStem Cell Factorphosphatidylinositol-3LADMatrix metalloproteinase-9left ventricular end-diastolic areamappolymerase chain reactionPCRmitogen-activated proteingreen fluorescent proteinleft anterior descendingejection fractionControlfractional shorteningchemokine receptor type 4
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Authors
Uswa BHSc, Guangming MD, Yaoguang MD, Terrence M. MD, MS,