| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2878684 | The Annals of Thoracic Surgery | 2010 | 6 Pages |
Abstract
Our results showed that glutamate receptor antagonism significantly reduced nitric oxide formation and neuronal apoptosis. We provide evidence that glutamate excitotoxicity mediates neuronal apoptosis in addition to necrosis after hypothermic circulatory arrest. Clinical glutamate receptor antagonists may have therapeutic benefits in ameliorating both types of neurologic injury after hypothermic circulatory arrest.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Elaine E. MD, Malcolm V. MD, Mary S. MA, Juan C. MD, Mary E. PhD, Charles J. MD, Michael V. MD, William A. MD,