| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2881519 | The Annals of Thoracic Surgery | 2007 | 8 Pages |
Abstract
Transforming growth factor-β1 causes SAVIC to calcify due to an early maximal increase in alkaline phosphatase activity with associated apoptotic events and increased matrix metalloproteinase 9. These TGF-β1-related mechanistic events may be of clinical relevance based upon the gene expression pattern changes observed in calcific aortic stenosis valve cusps.
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Authors
Jocelyn N. PhD, Jeanne M. MS, Elizabeth BS, Navneet R. MD, H. Scott PhD, Emile R. MD, Joseph H. MD, Robert C. MD, Robert J. MD,