| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2881954 | The Annals of Thoracic Surgery | 2007 | 7 Pages |
Abstract
C5a receptor blockade during simulated extracorporeal circulation completely blocked neutrophil β2 integrin upregulation and induction of plasma interleukin 8, suggesting an acute downregulatory effect on neutrophil chemotaxis-related pathways, while preserving terminal complement generation and neutrophil elastase release. Inhibition of leukocyte-platelet conjugate formation suggests a novel function for leukocyte adhesive receptors, possibly related to preservation of elastase generation.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Christine S. MD, Michael J. PhD, Henry M. MD, Daniel N. PhD, Robbin M. PhD, James E. PhD, Brian R. MD,