Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2882062 | The Annals of Thoracic Surgery | 2008 | 9 Pages |
Abstract
Primary graft dysfunction induces proinflammatory cytokines that can upregulate donor HLA-II antigens on the allograft. Increased donor HLA-II expression along with PGD-induced allograft inflammation promotes the development of donor specific alloimmunity. This provides an important mechanistic link between early posttransplant lung allograft injury and reported association with broncholitis obliterans syndrome.
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Authors
Ankit MD, Elbert MD, Nancy MS, Aviva RN, Ramsey MD, Elbert P. MD, G. Alexander MD, Bryan F. MD, T. PhD,