| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2882550 | The Annals of Thoracic Surgery | 2007 | 8 Pages |
Abstract
Regulatory inhibition of GSK-3β by Akt-1 in hypertrophied hearts is impaired, leading to activation during ischemia. Inhibition of GSK-3β by Li or IMI improves tolerance to ischemia/reperfusion injury in hypertrophied myocardium. The likely protective mechanism is an increase in insulin-mediated glucose uptake, resulting in greater substrate availability for glycolysis during ischemia and early reperfusion.
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Authors
Rodrigo MD, MBA, Ingeborg MD, Hung PhD, Joseph F. DVM, Pedro J. MD,