Effects of Annular Size, Transmitral Pressure, and Mitral Flow Rate on the Edge-To-Edge Repair: An In Vitro Study

With annular dilation, mitral regurgitation persisted even after the edge-to-edge repair. The edge-to-edge repair does not cause clinically relevant mitral valve stenosis in a normal size mitral valve. Mitral flow rate and transmitral pressure are the main determinants of FA during the cardiac cycle. Increasing annular area increases FA during systole but decreases FA during diastole. Systolic FA may become dominant with increases in MAA or peak transmitral pressure, or both.