| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2883493 | The Annals of Thoracic Surgery | 2006 | 7 Pages |
Abstract
NVP-AEW541 has a concentration-dependent inhibitory effect on mesothelioma cells in culture. NVP-AEW541 acts by inhibition of IGF-1R phosphorylation. Inhibition effects phosphorylation of downstream mediators in a dose-dependent fashion. Inhibition of the IGF pathway decreases viability of mesothelioma cell culture. Further evaluation of NVP-AEW541, and other selective IGF-1R inhibitors, may play an important role in multimodal treatment of malignant mesothelioma.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Bryan A. MD, Blake A. PhD, Sandra MD, Manish R. MD, Douglas MD, Michael A. MD, Robert A. MD,