Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2883704 | The Annals of Thoracic Surgery | 2006 | 7 Pages |
Abstract
Although early apoptotic signaling events (Bax translocation) are not prevented by diazoxide, addition of the mitochondrial-selective adenosine triphosphate-sensitive potassium-channel opener to the cardioplegic solution is associated with protection of mitochondrial structural and functional integrity in a clinically relevant model of neonatal cardiac surgery. The mitochondrial-protective effects of diazoxide may contribute to improved postoperative myocardial function in the neonate.
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Authors
Lixing MD, PhD, Caroline MS, James M. MD, Wei MD, Zhongdong MD, Wenyu MD, Christopher A. MD,