Article ID Journal Published Year Pages File Type
2883704 The Annals of Thoracic Surgery 2006 7 Pages PDF
Abstract
Although early apoptotic signaling events (Bax translocation) are not prevented by diazoxide, addition of the mitochondrial-selective adenosine triphosphate-sensitive potassium-channel opener to the cardioplegic solution is associated with protection of mitochondrial structural and functional integrity in a clinically relevant model of neonatal cardiac surgery. The mitochondrial-protective effects of diazoxide may contribute to improved postoperative myocardial function in the neonate.
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Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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