| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2883785 | The Annals of Thoracic Surgery | 2006 | 8 Pages |
Abstract
Although sildenafil induces a transient pulmonary vasodilation, it mediates a sustained change in vascular reactivity, especially to birth-related stimuli in the ovine fetal lung. These data suggest that PDE5 is involved in the regulation of pulmonary vascular reactivity during the perinatal period and may potentiate birth-related pulmonary vasodilator stimuli.
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Authors
Sophie MD, PhD, Benoît MD, Philippe MD, Anne MD, Thameur MD, Ghazwan MD, Laurent MD,