Article ID Journal Published Year Pages File Type
2887686 Annals of Vascular Surgery 2009 6 Pages PDF
Abstract
We report the use of high-resolution, phase-sensitive ultrasound speckle tracking to measure the local vessel-wall strain in two subjects with artery-vein bypass grafts. In addition, we combined this technique with a free-hand pressure equalization procedure to elucidate the nonlinear effects of blood pressure on vessel wall compliance. While conventional ultrasound imaging can be used to elucidate the mechanical properties of tissues within the body, it is constrained by comparatively lower resolution and inferential, rather than direct, measurements of strain and by the small strain normally produced under physiological pressure in highly nonlinear structures such as arteries. One of our subjects was examined both before and after developing stenosis 3 months postsurgery. The strain values for this individual were found to be significantly lower, indicating a stiffer vessel wall at the stenotic region than at a nonstenotic region under both physiological and equalized pressure. These results suggest the possibility of noninvasive detection of neointimal hyperplasia preceding anastomotic stenosis.
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