Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2888009 | Annals of Vascular Surgery | 2010 | 4 Pages |
Abstract
Thromboangiitis obliterans (also known as Buerger's disease) is an inflammatory vascular disorder that affects small and medium-sized arteries and veins in the extremities. There is no specific treatment and the only effective intervention is absolute cessation of tobacco use. Endothelial dysfunction appears to be of relevance to this condition and a report has even found that high serum levels of endothelin correlate with the presence of necrosis. We report two cases of digital necrosis showing a very satisfactory response to treatment with bosentan, a dual endothelin receptor antagonist.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
José A. Todoli Parra, Manuel Miralles Hernández, Manuel A. Arrébola López,