| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2892898 | Atherosclerosis | 2011 | 9 Pages |
ObjectiveResults from the published studies on the association of peroxisome proliferator activated receptor-gamma 2 (PPARγ2) Pro12Ala polymorphism with blood lipids are conflicting. In this meta-analysis, we investigated the association of the Pro12Ala polymorphism with total cholesterol, triglycerides, low density lipoprotein cholesterol, and high-density lipoprotein cholesterol.Methods74 studies with 52,998 subjects were included in this meta-analysis. Dominant model and additive model were used for this meta-analysis.ResultsWe did not detect significant overall association of the Pro12Ala polymorphism with total cholesterol, low density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P > 0.05). Under dominant model, significant association between the PPARγ2 Pro12Ala polymorphism and increased blood TC in male subjects was detected: standardized mean difference = 0.10, 95% confidence interval (0.02, 0.22), P = 0.02, Pheterogeneity = 0.14. We found a marginal association of the Pro12Ala polymorphism with increased HDL-C in healthy subjects under dominant model: standardized mean difference = 0.10, 95% confidence interval (−0.00, 0.20), P = 0.06, Pheterogeneity = 0.96. We also found subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians: for analysis including the outlier studies: SMD = −0.40, 95% CI (−0.76, −0.05), P = 0.02, Pheterogeneity < 0.00001, and for analysis excluding the outlier studies: SMD = −0.23, 95% CI (−0.39, −0.06), P = 0.006, Pheterogeneity = 0.86.ConclusionsOur meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood TC in male subjects, and marginally significant increased blood HDL-C in healthy subjects. Our meta-analysis also supports that subjects with genotype AlaAla have lower blood TG than subjects with genotype ProPro in Caucasians.
