| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2892956 | Atherosclerosis | 2010 | 6 Pages |
The comparative effects of aerobic and resistance exercise on triglyceride-rich lipoproteins including remnant lipoproteins are controversial. This study examined exercise effect on remnant-like lipoprotein particle cholesterol (RLP-C) in type 2 diabetes. Participants were randomized to control (Control), aerobic (Aerobic), resistance (Resistance), or both (Combined) exercise groups. Baseline and 6-month fasting RLP-C and apolipoprotein B48 concentrations were measured. Data analysis was on an intention-to-treat basis.At 6 months, RLP-C was lower in all groups; ΔRLP-C mg/dl, (95% confidence interval), Control −3.91, (−6.21 to −1.6), p = 0.001; Aerobic −3.89, (−6.41 to −1.36), p = 0.003, Resistance −7.52, (−9.89 to −5.15), p = 0.0001, Combined −7.50, (−9.87 to −5.13), p = 0.0001. Total triglycerides were significantly lower in Resistance and Combined groups only; −17.7 mg/dl (−32.8 to −2.7), p = 0.02 and −27.5 (−42.5 to −11.5), p = 0.001, respectively. Inter-group comparisons showed no difference in RLP-C change between Aerobic and Control and a significant difference in RLP-C change only where groups incorporating resistance exercise were compared with those without. There was no significant difference in RLP-C change between Resistance and Combined. Inter-group comparisons of total triglycerides change were significant only between Combined and Control. Changes in apolipoprotein B48 were not significant in inter-group comparisons.In conclusion, our data indicate that resistance exercise training, not aerobic, lowers RLP-C in type 2 diabetes. This effect was not revealed by changes in total triglycerides and apolipoprotein B48. The discordance between changes in RLP-C and apolipoprotein B48 in response to resistance exercise may indicate (a) a decrease in VLDL remnant and not chylomicron remnant particle number and/or (b) a depletion of cholesterol in chylomicron and/or VLDL remnants.
