Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2894728 | Atherosclerosis | 2008 | 6 Pages |
Abstract
Statin-mediated alteration in DC-cholesterol synthesis and subsequent activation of the Akt/NOS pathway accounts for the statin-induced decrease in DC invasion at low-moderate concentrations (0.05-0.5 μM). Additionally, at high statin concentrations (1 μM) DC invasion is reduced by inhibition of protein geranylgeranylation. As DCs control immunity, regulating DC/endothelial cell interaction by statins may have relevance to inflammation and atherogenesis.
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Authors
Sieglinde Kofler, Christoph Schlichting, Sarika Jankl, Thomas Nickel, Michael Weis,