Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2899197 | Cardiovascular Pathology | 2010 | 4 Pages |
Abstract
Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).
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Authors
Naoki Edo, Kosuke Miyai, Sho Ogata, Kuniaki Nakanishi, Sadayuki Hiroi, Susumu Tominaga, Satoshi Aiko, Toshiaki Kawai,