Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2899327 | Cardiovascular Pathology | 2011 | 11 Pages |
Abstract
Dysplastic semilunar valves displayed alterations in collagen and elastic fiber turnover that were distinct from valves similarly exposed to altered hemodynamics as well as to control valves. These results demonstrate that dysplastic valves are not simply valves with gross changes or loss of leaflet layers, but contain complex matrix and cell phenotype changes that, with future study, could potentially be targets for novel nonsurgical treatments.
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Authors
Elizabeth H. Stephens, Jennifer Shangkuan, Joyce J. Kuo, Joshua L. Carroll, Debra L. Kearney, Kathleen E. Carberry, Charles D. Jr, K. Jane Grande-Allen,