Impact of a Clinical Decision Support System in an Electronic Health Record to Enhance Detection of α1-Antitrypsin Deficiency

Issuing an alert within an EHR was associated with a severalfold increase in the frequency of testing for α1-antitrypsin without a higher rate of diagnosing severe AATD. While the lack of more frequent diagnosis of AATD may reflect a high rate of baseline detection, these results prompt consideration of additional strategies to enhance detection of AATD.