Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2905583 | Chest | 2006 | 6 Pages |
Abstract
Cigarette smoking is associated with a blunted vasodilator response to inhaled albuterol in the airway as an expression of endothelial dysfunction, with a partial recovery of albuterol responsiveness after smoking cessation in healthy ex-smokers but not in ex-smokers with COPD. In the latter group, combined glucocorticoid/long-acting β2-adrenergic agonist treatment restores albuterol responsiveness. The role of endothelial dysfunction in the physiopathology of COPD remains to be examined.
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Authors
Mendes MD, Campos MD, Wanner MD,