Article ID Journal Published Year Pages File Type
2909796 Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2016 4 Pages PDF
Abstract

AimsThe growing prevalence of obesity and its related metabolic disorders in adolescents shows the necessity of urgent focus on the related factors. Adipocytes secretions and their pro- or anti-inflammatory roles play effective roles in adipocytes metabolism. We assessed the relation between adiponectin, chemerin and lipid profile in hit phase of life.MethodsThis case–control study conducted on 78 adolescent girls, divided based on BMI percentile. Serum chemerin, adiponectin, lipid profile and body fat mass were measured. Data were analyzed using Pearson correlation test. The interactive relation between these variables was assessed using Structural Equation Modeling (SEM). Data were analyzed using SPSS software and AMOS software.ResultsChemerin were correlated significantly with triglyceride (r = 0.584 versus r = 0.319), HDL-cholestrol (r = −0.323 versus r = −0.335), LDL-cholestrol (r = 0.368 versus r = 0.327) and fat mass (r = 0.372 versus r = 0.357) in obese versus non-obese girls; while the mentioned correlation were non-significant with total cholesterol in obese group (r = 0.233 versus r = 0.336). Furthermore, there were significant association between adiponectin and triglyceride (r = −0.404 versus r = −0.317), HDL-cholesterol (r = 0.332 versus r = 0.316) and fat mass (r = −0.529 versus r = −0.346) in obese versus non-obese girls, respectively.ConclusionThere were positive associations between lipid profile components and serum chemerin levels. Adiponectin levels were in positive correlation with HDL-cholesterol concentrations. Chemerin showed positive correlations with potent health threatening components of lipid profile including triglyceride and cholesterol levels in adolescents.

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