Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2922313 | Heart Rhythm | 2012 | 11 Pages |
Abstract
The calcineurin pathway seems not to be involved in long-term cardiac remodeling of the chronic AV block dog. Although CaMKII is chronically activated, this does not translate to HDAC4 phosphorylation. However, acute CaMKII overactivation is able to initiate arrhythmias based on triggered activity.
Keywords
HDAC4MEF2Torsades de pointesEADCNATDPANPAPDSTVCAVBCaMKIIROSArrhythmiasearly afterdepolarizationCSAVentricular remodelingleft ventricleShort-term variabilitycyclosporin Amyocyte enhancer factor 2Action potential durationmapHistone deacetylase 4polymerase chain reactionPCRMonophasic action potentialatrial natriuretic peptideCalcineurinReactive oxygen species
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Authors
Vincent J.A. Msc, Marieke MD, PhD, Jet D.M. Beekman, Roel Bsc, Marien J.C. Bsc, Lars F. Bsc, Gudrun PhD, Karin MD, PhD, Leon J. PhD, Toon A.B. PhD, Marc A. PhD,