Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2922616 | Heart Rhythm | 2012 | 9 Pages |
Abstract
The R222Q mutation enhances cardiac sodium channel excitability, resulting in an unusual, highly penetrant phenotype of escape capture bigeminy and cardiomyopathy. These findings support the conclusion that a mutation in the voltage sensor of cardiac sodium channels can cause bigeminal arrhythmia associated with cardiomyopathy.
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Authors
Krishnakumar MBBS, Roman PhD, Louise MBChB, Melanie MD, Chantal MD, Talha MBBS, Peter H. PhD, Elod MD, Kumaraswamy MD,