Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction

Article ID	Journal	Published Year	Pages	File Type
2923223	Heart Rhythm	2010	7 Pages	PDF

Abstract

Nav1.4 channels in myocardium surviving 1 week infarction increases longitudinal but not transverse CV, consistent with the increased dV/dtmax and with the cellular localization of Nav1.4.

Keywords

PBS GFP MDP Nav1.4 dV/dtmax Arrhythmias Myocardial infarction left ventricle Conduction velocity Skeletal muscle Phosphate-buffered saline Conduction green fluorescent protein Gene therapy Sodium Channel

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

Preview

Cardiac expression of skeletal muscle sodium channels increases longitudinal conduction velocity in the canine 1-week myocardial infarction

Authors

Ruben MD, PhD, David H. MD, PhD, Eugene A. PhD, Michiel J. MD, PhD, Peter PhD, Evgeny P. PhD, Francien J.G. Wilms-Schopman, Tobias PhD, Iryna N. MD, Nazira MD, PhD, Kevin DVM, Yelena PhD, Ira S. MD, PhD, Richard B. PhD, Michael R. MD,