| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2923313 | Heart Rhythm | 2010 | 7 Pages |
Abstract
LVP initiates myocardial angiotensin II production and reactive oxygen species synthesis, leading to CREB ubiquitination and its proteasomal degradation. This sequence of events would explain the pacing-induced reduction in KChIP2, and contribute to altered repolarization and the T-wave changes of cardiac memory.
Keywords
NRCMTFACREBROSAngiotensin IITrifluoroacetic acidleft ventricle/ventricularProteasomal degradationCardiac memoryleft atrium/atrialLADcAMP response element binding proteincyclic adenosine monophosphate response element binding proteinleft anterior descendingneonatal rat ventricular cardiomyocytesReactive oxygen speciesubiquitination
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Authors
Nazira MD, PhD, David H. MD, PhD, Iryna N. MD, Warren MD, Steven J. PhD, Peter PhD, Michael R. MD,