Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2924096 | Heart Rhythm | 2008 | 9 Pages |
Abstract
Homozygous HERG Q1070X is equivalent to near functional knockout of HERG. Clinical consequences appear early, originating during the early stages of embryonic life. The NMD pathway renders HERG Q1070X functionless before it can form a functional ion channel.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Zahurul A. MD, PhD, Tarek S. MD, FACC, Qiuming MD, PhD, Ahmad S. MD, Saleh Al MD, Julene S. MD, PhD, Tessa MD, MRCP, Marcel M.A.M. PhD, Zhengfeng MD, PhD, Arthur A.M. MD, PhD,