Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2924477 | Heart Rhythm | 2009 | 8 Pages |
Abstract
KChIP2 deficiency eliminated HpTx-2-sensitive Ito,f, but had little impact on total APD, secondary to upregulation of 4-AP-sensitive IK,slow in association with increased KV1.5 expression. There is increased sensitivity to 4-AP-mediated APD prolongation in KChIP2â/â. Thus, KChIP2 seems important for murine repolarization in circumstances of reduced repolarization reserve.
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Authors
Morten B. PhD, Eugene A. PhD, Evgeny P. PhD, Nazira MD, PhD, Penelope A. PhD, FHRS, Michael R. MD, FHRS,