Article ID Journal Published Year Pages File Type
2924477 Heart Rhythm 2009 8 Pages PDF
Abstract
KChIP2 deficiency eliminated HpTx-2-sensitive Ito,f, but had little impact on total APD, secondary to upregulation of 4-AP-sensitive IK,slow in association with increased KV1.5 expression. There is increased sensitivity to 4-AP-mediated APD prolongation in KChIP2−/−. Thus, KChIP2 seems important for murine repolarization in circumstances of reduced repolarization reserve.
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