Consistencies of 3D TTE global longitudinal strain of both ventricles between assessors were worse for 2D, but better for 3D ventricular EF

•Consistencies of independent TTE estimates between 2 assessors of 3D LV GLS were good as well as 2D LV GLS and 3D LV volume.•Those of 3D RV GLS were worse than those of 2D RV GLS, 3D RV EDV and 3D RV ESV in a population containing 74% HCM patients.•The consistencies of independent TTE estimates between the two assessors of 3D LV EF and 3D RV EF were both very poor.•It may be difficult to evaluate cardiac function accurately from 3D measurements on 3D TTE because of operator dependence.•Thus, 2D and 3D GLS for LV and 2D GLS for RV, especially whole RV, may be preferable.

PurposeWe evaluated the consistency of different-assessors in estimating three-dimensional (3D) global-longitudinal-strain (GLS) of left (LV) and right ventricle (RV) using transthoracic-echocardiography (TTE) for LV and RV systolic-function. We compared results from two-independent-specialists using this-approach for 3D LV and RV parameters in a population with 74% hypertrophic-cardiomyopathy (HCM) patients.Methods58 patients (43 HCM (32 male; 62 ± 15 years) and 15 controls (5 male; 53 ± 22 years)) underwent TTE (Vivid-E9) to measure 2D and 3D GLS of the LV and RV by two-independent-specialists.ResultsConsistencies of estimates of 3D LV end-diastolic volume (EDV), end-systolic volume (ESV), and ejection-fraction (EF) between the two-assessors were 0.872 (3D LVEDV, P < 0.001), 0.797 (3D LVESV, P < 0.001), and 0.215 (3D LVEF, P = 0.105). Consistencies of 2D and 3D LV GLS between two-assessors were 0.900 (2D LVGLS, P < 0.001) and 0.874 (3D LVGLS, P < 0.001). Consistencies of estimates of 3D RVEDV, RVESV, and RVEF between two assessors were 0.781 (3D RVEDV, P < 0.001), 0.755 (3D RVESV, P < 0.001), and 0.26 (3D RVEF, P = 0.049). Consistencies of 2D and 3D GLS of whole RV and those of RV free wall only between two-assessors were 0.886 (2D GLS of whole RV, P < 0.001), 0.687 (3D GLS of whole RV, P < 0.001), 0.707 (2D GLS of RV free wall, P < 0.001), and 0.630 (3D GLS of RV free wall, P < 0.001).ConclusionsConsistencies of independent-estimates of 3D GLS of the LV and RV using TTE between two-assessors were worse than for 2D GLS of the LV and RV, but better than for 3D LVEF and RVEF in a population with 74% HCM patients.