Elevated coronary calcium scores are associated with higher residual platelet aggregation after clopidogrel treatment in patients with stable angina pectoris

We found a significant correlation between ASE and RPA (r2 = 0.135, p = 0.0033, slope 7.809 ± 2.549). Patients within the first quartile of ASE had significantly lower RPA after administration of clopidogrel than other patients (p<0.05). Establishing a threshold of 200 ASE responsiveness to clopidogrel could be predicted with a positive predictive value of 80% and a specificity of 91%. In conclusion, we could demonstrate that patients with a low coronary plaque burden are more likely to have low RPA. Coronary calcium scoring might help to identify low responders to clopidogrel prior to stent placement and aggregometry.