Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2932752 | International Journal of Cardiology | 2010 | 4 Pages |
There is limited data on heart rate turbulence (HRT) in systemic sclerosis (SSc) patients, potentially threatened with cardiac autonomic dysfunction. We performed 24-hour Holter monitoring for HRT assessment in 45 patients with SSc and 30 healthy controls. Abnormal HRT defined as turbulence onset (TO) ≥ 0.0% and/or turbulence slope (TS) ≤ 2.5 ms/RR was found in 19 (42%) of SSc patients while not in controls. HRT was significantly impaired in SSc group, as compared to controls: a median of TO was higher (− 0.13 vs. − 2.45%, p = 0.0001), and a median of TS was lower (6.90 vs. 13.21 ms/RR, p = 0.0003), respectively. Multivariate analysis showed that abnormal HRT in SSc was significantly influenced by pulmonary hypertension (PH) (OR 6.1, 1.1–48.6; p = 0.049) and older age (OR 1.8, 95%CI 1.1–3.5; p = 0.03). In conclusion, HRT assessment indicates a frequent impairment of cardiac autonomic nervous system in SSc patients. Moreover, older age in these patients and especially PH are independent significant predictors of cardiac autonomic dysfunction.