| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2936505 | International Journal of Cardiology | 2007 | 7 Pages |
BackgroundTo test prospectively whether moderate hyperhomocysteinemia and low folate levels could have an influence in the prognosis of 155 patients who presented with an acute coronary syndrome.Methods and resultsAfter a mean follow-up of 13.4 ± 7.4 months, patients with low folate levels had higher percentages of cardiovascular death and major cardiovascular events (33% vs. 5%, p < 0.001; 44% vs. 22%, p < 0.05) and patients with high homocysteine levels had a higher percentage of major cardiovascular events (31% vs. 14.5%, p < 0.03). Kaplan–Meier survival estimates analysis showed that patients with low folate levels had a significantly higher probability of cardiovascular death and lower free-of-events survival (log rank statistic: 21.17, p < 0.001 and 6.59, p = 0.01). Patients with high homocysteine levels had a lower free-of-events survival (log rank statistic: 4.95, p = 0.02). Different survival multivariate analysis model showed that the presence of low folate levels was an independent predictor of cardiovascular death (hazard ratio 8.85, 95% confidence interval 2.6–29.3, p < 0.000) and high homocysteine levels was identified as independent predictor of major cardiovascular events (hazard ratio 2.34, 95% confidence interval 1.07–5.12, p < 0.03).ConclusionsLow folate levels and moderate hyperhomocysteinemia were identified as independent predictors of cardiovascular events in the follow-up.
