Article ID Journal Published Year Pages File Type
2966212 Journal of Clinical Lipidology 2011 9 Pages PDF
Abstract

BackgroundMetabolic syndrome (MetS) and atherosclerotic vascular disease (AVD) are associated with increased coronary heart disease risk.ObjectiveTo assess percent change from baseline in lipids and high-sensitivity C-reactive protein (hs-CRP) levels and the proportion of subjects reaching specified low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (HDL-C) and apolipoprotein B (Apo B) single, dual, and triple targets and hs-CRP <2 mg/L among subjects with and without AVD treated with ezetimibe/simvastatin or atorvastatin for 6 weeks.MethodsAdults (N = 1143) with MetS and hypercholesterolemia were randomized to starting and next higher doses of ezetimibe/simvastatin (10/20 or 10/40 mg) or atorvastatin (10, 20, or 40 mg).ResultsEzetimibe/simvastatin produced significantly greater reductions in evaluated lipids than atorvastatin for most prespecified dose comparisons. More subjects without AVD achieved LDL-C levels <100 mg/dL, non-HDL-C levels <130 mg/dL, and dual LDL-C/non-HDL targets (83%–92% vs 62%–76%) and Apo B <90 mg/dL or triple targets (65%–75% vs 41%–49%) with 40 mg of atorvastatin or 10/20–40 mg of ezetimibe/simvastatin compared with 10 or 20 mg of atorvastatin, respectively. More subjects with AVD achieved LDL-C<70 mg/dL and non-HDL-C<100 mg/dL single and dual targets (65%–80%) and Apo B <80 mg/dL (53%–63%) with 10/20–40 mg of ezetimibe/simvastatin than with 40 mg of atorvastatin (40%–49%). More subjects achieved triple lipid targets with 10/20–40 mg of ezetimibe/simvastatin versus 10–40 mg of atorvastatin (50%–63% vs 24%–40%). Achievement of hs-CRP <2 mg/L was similar across all doses regardless of AVD status.ConclusionsMore intensive therapy was required for >80% of subjects to achieve LDL-C <100 mg/dL and non-HDL-C <130 mg/dL and for the majority of subjects to achieve lower levels of LDL-C <70 mg/dL, non-HDL-C <100 mg/dL, and/or Apo B <90 mg/dL. The effect of ezetimibe on cardiovascular risk reduction has yet to be established. (Clintrials.gov no: NCT00409773)

Related Topics
Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
Authors
, , , , , , , , ,