Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2969600 | The Journal of Heart and Lung Transplantation | 2016 | 19 Pages |
Abstract
VEGF inhibition reduces the severity and incidence of CAV in mouse models of cardiac transplantation, while attenuating myocardial edema and neo-angiogenesis. Using this model, we provide in vitro evidence of the role of VEGF signaling in BM-mediated microvascular outgrowth and endothelial cell migration and proliferation. VEGF inhibition may represent a novel approach to CAV treatment and prevention.
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Authors
Safia BSc, MD, Brian W-C BMLSc, PhD, Jon M. BSc, PhD, Bruce M. PhD, MD,