Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2969670 | The Journal of Heart and Lung Transplantation | 2016 | 32 Pages |
Abstract
In this post-infarct heart failure model, either hESC-Pg or their secreted EV enhance recovery of cardiac function and similarly affect cardiac gene expression patterns that could be related to this recovery. Although the mechanisms by which EV improve cardiac function remain to be determined, these results support the idea that a paracrine mechanism is sufficient to effect functional recovery in cell-based therapies for post-infarction-related chronic heart failure.
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Authors
Anaïs MSc, Valérie BSc, Nadia MSc, Lousineh MSc, Valérie PharmD, PhD, Isabelle MSc, Hany MD, PhD, Marie-Cécile MSc, Hadi D. MD, MSc, MPH, Adèle PhD, Mathilde BSc, Min MD, PhD, Xavier PhD, Jérôme PhD, Albert MD, Marc MD, MPH, FRCSC, Chantal M. PhD,