Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2970028 | The Journal of Heart and Lung Transplantation | 2014 | 8 Pages |
Abstract
We identified incrementally increased apoptosis after myocardial unloading of the normal rat heart, which is exacerbated at late time points (60 days) and inversely related to loss of myocardial mass. Our findings suggest an irreversible detrimental effect of long-term unloading on myocardium that may be precluded by partial reloading and amenable to molecular therapeutic intervention.
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Authors
Henriette MD, Marie-Noelle PhD, Adrian MS, Celine MS, Sarah PhD, Nina D. PhD, Walter J. PhD, Patrick MD, Thierry P. MD, Hendrik T. MD, MBA,