Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2970247 | The Journal of Heart and Lung Transplantation | 2014 | 9 Pages |
Abstract
The HLHS RV has an abnormal myocardial gene expression pattern, downregulation of β1-AR, preserved cyclic adenosine monophosphate levels, and increased CaMKII activity compared with the non-failing control RV. There is MHC isoform switching, increased adenylyl cyclase 5, and increased phosphorylation of phospholamban threonine 17 only in the D-HLHS group. Although abnormal gene expression and changes in the β-AR system precede clinically evident ventricular failure in HLHS, additional unique adaptations occur in those with HLHS and failed surgical palliation.
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Authors
Shelley D. MD, Brian L. MD, Jeremy BS, Allen BS, Matthew Friedrich, Kurt PhD, Valencia BS, Karin MS, Penny BS, Rebecca BS, Kurt R. MD, Carmen C. PhD,