Anti-major histocompatibility complex-induced obliterative airway disease: Selective role for CD4 and CD8 T cells in inducing immune responses to self-antigens

Ligation of MHC molecules by its specific antibodies induced early injury with neutrophils, macrophages, and CD8 T cells, which leads to exposure of cryptic self-antigens and their presentation by the infiltrating CD4+ T cells and B cells, leading to the development of immune responses to self-antigens and culminating in obliterative airway disease.