Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2970580 | The Journal of Heart and Lung Transplantation | 2013 | 5 Pages |
Abstract
For the first time we show that skeletal muscle RyR1 from human heart failure is post-translationally modified, which corroborates previous data from experimental animal studies. This indicates pathologic Ca2+ release as a potential mechanism behind skeletal muscle weakness and impaired exercise tolerance in patients with heart failure and suggests a potential target for pharmacologic intervention.
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Authors
Eric MD, PhD, Daniel C. MD, PhD, Michael MD, Steven PhD, Donna M. MD, Andrew R. MD, Lars H. MD, PhD, Thomas MD, PhD,