Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: A single-center, retrospective study

Patients with DSA to Class I or to both Class I and II showed a correlation with C4d IF and had higher GF rates compared to patients with DSA to only Class II or no DSA; patients with DSA to Class II remained at risk for CAV. Episodes of ACR and CAV, but not AMR, appeared to be more frequently associated with graft dysfunction in patients with circulating DSA.