Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2971467 | The Journal of Heart and Lung Transplantation | 2010 | 7 Pages |
Abstract
Anti-HLA antibodies developed during the post-transplant period and α-defensins stimulated β-defensin production by epithelial cells, leading to increased cellular infiltration and inflammation. Chronic stimulation of epithelium by antibodies to MHC and resulting increased levels of defensins induce growth factor production and epithelial proliferation contributing to the development of chronic rejection after LTx.
Keywords
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Authors
Deepti PhD, Nataraju PhD, Venkataswarup MD, PhD, Naohiko MD, PhD, Sabarinathan PhD, Ramsey MD, Elbert MD, Brian MD, Alexander MD, Thalachallour PhD,