| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2971546 | The Journal of Heart and Lung Transplantation | 2011 | 9 Pages |
Abstract
Simvastatin treatment in MCT-PH rats not only attenuated pulmonary hypertension, but also desensitized PCF hypersensitivity and decreased the production of ROS. These cholesterol-independent effects were mainly through the HO-1 pathway and may all contribute to the therapeutic effects of PH treatment.
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Authors
Hsao-Hsun MD, PhD, Ting PhD, Wen-Je MD, PhD, Jo-Yu Hsu, Jin-Shing MD, PhD, Yung-Chie MD, PhD, I-Rue MD, PhD, Chau-Fong PhD,