Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2971693 | The Journal of Heart and Lung Transplantation | 2012 | 10 Pages |
Abstract
Simvastatin treatment inhibited adaptive T-cell alloimmune activation as depicted by reduced expression of lymphocyte chemokine and pro-inflammatory cytokine mRNA and reduced allograft infiltration by inflammatory cells. Importantly, simvastatin inhibits the development of OAD and this effect is partially mediated by increased nitric oxide activity. These results suggest a role for simvastatin in the prevention of obliterative bronchiolitis.
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Authors
Jussi O. MD, Simo O. MD, Maria MD, Raimo MD, Rainer MD, Mikko A. MD, Kirsi MD, Antti I. MD, PhD, Karl B. MD, PhD, Jussi M. MD, PhD,