Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2971834 | The Journal of Heart and Lung Transplantation | 2010 | 7 Pages |
Abstract
This study demonstrates that complement deposition is a frequent occurrence in the first 2 years post-transplantation. Although acute rejection is a known risk factor for CAV, in this study the relationship was found not to be significant. No relationship was found with the development of CAV and histologic features of AMR, when assessed by C4d deposition alone. However, an association between C3d deposition and the development of CAV was determined in this study group, suggesting that complement activation may play a role in the pathogenesis of CAV.
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Authors
Ellen L. BSc, Carl PhD, Linda D. PhD, John FRCS, Martin J. FRCPath,