| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2972071 | The Journal of Heart and Lung Transplantation | 2010 | 8 Pages |
Abstract
Increased protein expression of phosphorylated (inactivated) Rb and the pocket proteins is associated with cardiomyocyte hypertrophy in CHF. Rb inactivation might be explained by phosphorylation by increased numbers of cyclin D1/cdk4 complexes associated with cardiomyocyte hypertrophy. However, ventricular unloading can reversibly regulate this process. These data underscore the importance of cell cycle regulatory proteins in the pathogenesis of CHF-associated (maladaptive) cardiomyocyte hypertrophy and might offer novel clues for pharmacologic approaches of congestive heart failure.
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Authors
Jeremias MD, Klaus Jürgen MD, Atsushi MD, Nobuakira MD, Christian MD, Jörg MD, Christof MD, Hideo Andreas MD,